Int J Med Research Paper

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Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details

Research Paper
Salmonella Overcomes Drug Resistance in Tumor through P-glycoprotein Downregulation
Chih-Jen Yang, Wen-Wei Chang, Song-Tao Lin, Man-Chin Chen, Che-Hsin Lee
Int. J. Med. Sci. 2018; 15(6): 574-579. doi:10.7150/ijms.23285
[Abstract] [Full text] [PDF]

Research Paper
Dehydroepiandrosterone supplementation combined with Weight-Loading Whole-Body Vibration Training (WWBV) affects exercise performance and muscle glycogen storage in middle-aged C57BL/6 mice
Yi-Ming Chen, Hao-Chieh Lee, Mu-Tsung Chen, Chi-Chang Huang, Wen-Chyuan Chen
Int. J. Med. Sci. 2018; 15(6): 564-573. doi:10.7150/ijms.23352
[Abstract] [Full text] [PDF]

Research Paper
Vascular calcification and left ventricular hypertrophy in hemodialysis patients: interrelationship and clinical impacts
Hyeon Seok Hwang, Jung Sun Cho, Yu Ah Hong, Yoon Kyung Chang, Suk Young Kim, Seok Joon Shin, Hye Eun Yoon
Int. J. Med. Sci. 2018; 15(6): 557-563. doi:10.7150/ijms.23700
[Abstract] [Full text] [PDF]

Research Paper
Cervical Dilatation Curves of Spontaneous Deliveries in Pregnant Japanese Females
Yusuke Inde, Akihito Nakai, Atsuko Sekiguchi, Masako Hayashi, Toshiyuki Takeshita
Int. J. Med. Sci. 2018; 15(6): 549-556. doi:10.7150/ijms.23505
[Abstract] [Full text] [PDF]

Research Paper
miRNA-135b Contributes to Triple Negative Breast Cancer Molecular Heterogeneity: Different Expression Profile in Basal-like Versus non-Basal-like Phenotypes
Paolo Uva, Paolo Cossu-Rocca, Federica Loi, Giovanna Pira, Luciano Murgia, Sandra Orrù, Matteo Floris, Maria Rosaria Muroni, Francesca Sanges, Ciriaco Carru, Andrea Angius, Maria Rosaria De Miglio
Int. J. Med. Sci. 2018; 15(6): 536-548. doi:10.7150/ijms.23402
[Abstract] [Full text] [PDF]

Research Paper
ADVANCIS Score Predicts Acute Kidney Injury After Percutaneous Coronary Intervention for Acute Coronary Syndrome
Pei-Chun Fan, Tien-Hsing Chen, Cheng-Chia Lee, Tsung-Yu Tsai, Yung-Chang Chen, Chih-Hsiang Chang
Int. J. Med. Sci. 2018; 15(5): 528-535. doi:10.7150/ijms.23064
[Abstract] [Full text] [PDF]

Research Paper
Atorvastatin Attenuates Metabolic Remodeling in Ischemic Myocardium through the Downregulation of UCP2 Expression
Chunyan Yang, Dongming Zhao, Guohui Liu, Haikuo Zheng, Hongliang Yang, Sibao Yang, Ping Yang
Int. J. Med. Sci. 2018; 15(5): 517-527. doi:10.7150/ijms.22454
[Abstract] [Full text] [PDF]

Research Paper
Dexamethasone Down-regulates Osteocalcin in Bone Cells through Leptin Pathway
Shu-Mei Chen, Yi-Jen Peng, Chih-Chien Wang, Sui-Lung Su, Donald M Salter, Herng-Sheng Lee
Int. J. Med. Sci. 2018; 15(5): 507-516. doi:10.7150/ijms.21881
[Abstract] [Full text] [PDF]

Research Paper
Synthesis and in vitro experiments of carcinoma vascular endothelial targeting polymeric nano-micelles combining small particle size and supermagnetic sensitivity
Yi Zhang, Jielin Pan, Qilan Xu, Hao Li, Jianhao Wang, Chao Zhang, Guobin Hong
Int. J. Med. Sci. 2018; 15(5): 498-506. doi:10.7150/ijms.23146
[Abstract] [Full text] [PDF]

Review
Decellularized Hydrogels in Bone Tissue Engineering: A Topical Review
Andrea Pacifici, Luigi Laino, Marco Gargari, Federico Guzzo, Andrea Velandia Luz, Antonella Polimeni, Luciano Pacifici
Int. J. Med. Sci. 2018; 15(5): 492-497. doi:10.7150/ijms.22789
[Abstract] [Full text] [PDF]

Research Paper
Impact of placental weight and fetal/placental weight ratio Z score on fetal growth and the perinatal outcome
Yoshio Matsuda, Toshiya Itoh, Hiroaki Itoh, Masaki Ogawa, Kemal Sasaki, Naohiro Kanayama, Shigeki Matsubara
Int. J. Med. Sci. 2018; 15(5): 484-491. doi:10.7150/ijms.23107
[Abstract] [Full text] [PDF]

Research Paper
Orofacial Manifestations and Temporomandibular Disorders of Sjögren Syndrome: An Observational Study
Vito Crincoli, Mariasevera Di Comite, Mariateresa Guerrieri, Rossana Patricia Rotolo, Luisa Limongelli, Angela Tempesta, Florenzo Iannone, Angela Rinaldi, Giovanni Lapadula, Gianfranco Favia
Int. J. Med. Sci. 2018; 15(5): 475-483. doi:10.7150/ijms.23044
[Abstract] [Full text] [PDF]

Research Paper
Persistent Hepatic Inflammation Plays a Role in Hepatocellular Carcinoma After Sustained Virological Response in Patients with HCV Infection
Kazushige Nirei, Tatsuo Kanda, Hitomi Nakamura, Shunichi Matsuoka, Tadatoshi Takayama, Masahiko Sugitani, Mitsuhiko Moriyama
Int. J. Med. Sci. 2018; 15(5): 466-474. doi:10.7150/ijms.23147
[Abstract] [Full text] [PDF]

Research Paper
Is pharmacologic treatment better than neural mobilization for cervicobrachial pain? A randomized clinical trial
César Calvo-Lobo, Francisco Unda-Solano, Daniel López-López, Irene Sanz-Corbalán, Carlos Romero-Morales, Patricia Palomo-López, Jesús Seco-Calvo, David Rodríguez-Sanz
Int. J. Med. Sci. 2018; 15(5): 456-465. doi:10.7150/ijms.23525
[Abstract] [Full text] [PDF]

Research Paper
Downregulation of MiR-203a Disinhibits Bmi1 and Promotes Growth and Proliferation of Keratinocytes in Cholesteatoma
Jian Zang, Lian Hui, Ning Yang, Bo Yang, Xuejun Jiang
Int. J. Med. Sci. 2018; 15(5): 447-455. doi:10.7150/ijms.22410
[Abstract] [Full text] [PDF]

Research Paper
A New Look at Etiological Factors of Idiopathic Scoliosis: Neural Crest Cells
Alla M. Zaydman, Elena L. Strokova, Elena V. Kiseleva, Lubov A. Suldina, Anton A. Strunov, Alexander I. Shevchenko, Pavel P. Laktionov, Vladimir M. Subbotin
Int. J. Med. Sci. 2018; 15(5): 436-446. doi:10.7150/ijms.22894
[Abstract] [Full text] [PDF]

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International Journal of Medical Informatics provides an international medium for dissemination of original results and interpretative reviews concerning the field of medical informatics. The Journal emphasizes the evaluation of systems in healthcare settings.
The scope of journal covers:

  • Information systems, including national or international registration systems, hospital information systems, departmental and/or physician's office systems, document handling systems, electronic medical record systems, standardization, systems integration etc.;
  • Computer-aided medical decision support systems using heuristic, algorithmic and/or statistical methods as exemplified in decision theory, protocol development, artificial intelligence, etc.
  • Educational computer based programs pertaining to medical informatics or medicine in general;
  • Organizational, economic, social, clinical impact, ethical and cost-benefit aspects of IT applications in health care.

Short technical communications concerning (solved) problems in implementing or using existing information systems are welcome. Review articles concerning subjects falling in the scope of the journal are also invited.

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